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This study was partially supported by a grant (PI 19/00458) from the Instituto de Salud Carlos III (Spanish Ministry of Science and Innovation, Madrid, Spain and European Regional Development Fund-ERDF); a grant (016/2019) from the Fundacion DISA (Las Palmas, Spain); a grant (BF1-19-13) from the Fundacion Espanola del Dolor (Spanish Pain Foundation, Madrid, Spain); a grant (ENF22/10) from the Fundacion Canaria Instituto Investigacion Sanitaria de Canarias (FIISC), Las Palmas, Spain; and a grant (CIGC2021) from the Cabildo de Gran Canaria, Las Palmas, Spain. During this work, S.C.R. was funded by a postdoctoral Grant Margarita Salas from Ministerio de Universidades, Fondos Next Generation EU, and Universidad de la Laguna (UNI/551/2021).

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Effects of Ozone Treatment on Health-Related Quality of Life and Toxicity Induced by Radiotherapy and Chemotherapy in Symptomatic Cancer Survivors

Publicado en:International Journal of Environmental Research and Public Health. 20 (2): 1479- - 2023-01-01 20(2), DOI: 10.3390/ijerph20021479

Autores: Clavo, Bernardino; Canovas-Molina, Angeles; Ramallo-Farina, Yolanda; Federico, Mario; Rodriguez-Abreu, Delvys; Galvan, Saray; Ribeiro, Ivone; Marques da Silva, Susana C; Navarro, Minerva; Gonzalez-Beltran, Damian; Diaz-Garrido, Juan A; Cazorla-Rivero, Sara; Rodriguez-Esparragon, Francisco; Serrano-Aguilar, Pedro

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(1) Background: The continuous improvement in cancer treatment has led to improvement in patients' survival and a subsequent increase in the number of cancer survivors living with adverse side effects of cancer treatments, sometimes with a high and adverse impact on their health-related quality of life (HRQOL). Side effects of cancer treatments are frequently associated with chronic status of oxidative stress, inflammation, and/or ischemia. The potential for ozone treatment to modulate those processes and improve some of those adverse effects has previously been described. The aim of this study was to evaluate the effect of ozone treatment on the HRQOL and grade of toxicity in symptomatic cancer survivors. (2) Methods: Before and after ozone treatment, we assessed (i) the HRQOL (according to the EQ-5D-5L questionnaire) and (ii) the grade of toxicity (according to the Common Terminology Criteria for Adverse Events of the National Cancer Institute of EEUU (CTCAE v.5.0)) in 26 cancer survivors with chronic side effects of radiotherapy and chemotherapy. (3) Results: There was a significant (p < 0.001) improvement in the EQ-5D-5L index as per the self-reported outcome evaluation of patients' health status. All the dimensions of the EQ-5D-5L questionnaire (mobility, self-care, activities, pain/discomfort, and anxiety/depression) and the self-evaluation of the health status using the visual analog scale were significantly improved (p < 0.05). The grade of toxicity was also significantly decreased (p < 0.001). (4) Conclusions: In cancer survivors with chronic side effects of cancer treatment, ozone treatment can improve the grade of toxicity and the HRQOL. These results merit additional research. Further studies are ongoing.

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