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This study was partially supported by a grant (PI 19/00458) from the Instituto de Salud Carlos III (Spanish Ministry of Science and Innovation, Madrid, Spain and European Regional Development Fund-ERDF); a grant (016/2019) from the Fundacion DISA (Las Palmas, Spain); a grant (BF1-19-13) from the Fundacion Espanola del Dolor (Spanish Pain Foundation, Madrid, Spain); a grant (ENF22/10) from the Fundacion Canaria Instituto Investigacion Sanitaria de Canarias (FIISC), Las Palmas, Spain; and a grant (CIGC2021) from the Cabildo de Gran Canaria, Las Palmas, Spain. During this work, S.C.R. was funded by a postdoctoral Grant Margarita Salas from Ministerio de Universidades, Fondos Next Generation EU, and Universidad de la Laguna (UNI/551/2021).

Analysis of institutional authors

Gonzalez-Beltran, DamianAuthor

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Article

Effects of Ozone Treatment on Health-Related Quality of Life and Toxicity Induced by Radiotherapy and Chemotherapy in Symptomatic Cancer Survivors

Publicated to:International Journal of Environmental Research and Public Health. 20 (2): 1479- - 2023-01-01 20(2), DOI: 10.3390/ijerph20021479

Authors: Clavo, Bernardino; Canovas-Molina, Angeles; Ramallo-Farina, Yolanda; Federico, Mario; Rodriguez-Abreu, Delvys; Galvan, Saray; Ribeiro, Ivone; Marques da Silva, Susana C; Navarro, Minerva; Gonzalez-Beltran, Damian; Diaz-Garrido, Juan A; Cazorla-Rivero, Sara; Rodriguez-Esparragon, Francisco; Serrano-Aguilar, Pedro

Affiliations

Complejo Hosp Univ Insular Materno Infantil, Med Oncol Dept, Las Palmas Gran Canaria 35016, Spain - Author
Dr Negrin Univ Hosp, Chron Pain Unit, Las Palmas Gran Canaria 35019, Spain - Author
Fdn Canaria Inst Invest Sanitaria Canarias FIISC, Las Palmas Gran Canaria 35019, Spain - Author
Hosp Univ Dr Negrin, Radiat Oncol Dept, Las Palmas Gran Canaria 35019, Spain - Author
Hosp Univ Gran Canaria Dr Negrin, Med Oncol Dept, Las Palmas Gran Canaria 35019, Spain - Author
Hosp Univ Gran Canaria Dr Negrin, Psychiat Dept, Las Palmas Gran Canaria 35019, Spain - Author
Hosp Univ Gran Canaria Dr Negrin, Res Unit, Las Palmas Gran Canaria 35019, Spain - Author
Inst Salud Carlos III, CIBER Enfermedades Infecciosas CIBERINFEC, Madrid 28029, Spain - Author
Inst Salud Carlos III, Network Res Chron Primary Care & Hlth Promot RICA, Madrid 28029, Spain - Author
Serv Evaluac & Planificac Serv Canario Salud SESC, Tenerife 38109, Spain - Author
Spanish Grp Clin Res Radiat Oncol GICOR, Madrid 28290, Spain - Author
Univ La Laguna, Inst Tecnol Biomed ITB, San Cristobal la Laguna 38296, Spain - Author
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38296, Spain - Author
Univ La Laguna, San Cristobal la Laguna 38296, Spain - Author
Univ Las Palmas Gran Canaria, Universitary Inst Res Biomed & Hlth iUIBS, Mol & Translat Pharmacol Grp, Las Palmas Gran Canaria 35016, Spain - Author
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Abstract

(1) Background: The continuous improvement in cancer treatment has led to improvement in patients' survival and a subsequent increase in the number of cancer survivors living with adverse side effects of cancer treatments, sometimes with a high and adverse impact on their health-related quality of life (HRQOL). Side effects of cancer treatments are frequently associated with chronic status of oxidative stress, inflammation, and/or ischemia. The potential for ozone treatment to modulate those processes and improve some of those adverse effects has previously been described. The aim of this study was to evaluate the effect of ozone treatment on the HRQOL and grade of toxicity in symptomatic cancer survivors. (2) Methods: Before and after ozone treatment, we assessed (i) the HRQOL (according to the EQ-5D-5L questionnaire) and (ii) the grade of toxicity (according to the Common Terminology Criteria for Adverse Events of the National Cancer Institute of EEUU (CTCAE v.5.0)) in 26 cancer survivors with chronic side effects of radiotherapy and chemotherapy. (3) Results: There was a significant (p < 0.001) improvement in the EQ-5D-5L index as per the self-reported outcome evaluation of patients' health status. All the dimensions of the EQ-5D-5L questionnaire (mobility, self-care, activities, pain/discomfort, and anxiety/depression) and the self-evaluation of the health status using the visual analog scale were significantly improved (p < 0.05). The grade of toxicity was also significantly decreased (p < 0.001). (4) Conclusions: In cancer survivors with chronic side effects of cancer treatment, ozone treatment can improve the grade of toxicity and the HRQOL. These results merit additional research. Further studies are ongoing.

Keywords

American societyAnxietAnxiety and depressionCancer survivorsChemotherapy-induced neuropathyChemotherapy-induced side effectsCross-sectional studiesDepressionHealth statusHealth-related quality of lifeHumansInduced peripheral neuropathyManagementNeoplasmsOzone therapyPaiPainPrevalenceQuality of lifeRadiation-induced side effectsRectal insufflationSurveys and questionnairesTherapy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal of Environmental Research and Public Health due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Public Health, Environmental and Occupational Health.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 9.75, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-24, the following number of citations:

  • WoS: 4
  • Scopus: 9
  • Europe PMC: 2
  • OpenCitations: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-24:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 29.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 29 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.3.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.