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Analysis of institutional authors

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October 10, 2022
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Polyfunctionalized alpha-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment

Publicated to: Antioxidants. 11 (9): 1735- - 2022-09-01 11(9), DOI: 10.3390/antiox11091735

Authors:

Diez-Iriepa, D; Knez, D; Gobec, S; Iriepa, I; de los Rios, C; Bravo, I; Lopez-Munoz, F; Marco-Contelles, J; Hadjipavlou-Litina, D
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Affiliations

Alcala Univ, Inst Chem Res Andres M del Rio, Alcala De Henares 28805, Spain - Author
Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece - Author
Autonomous Univ Madrid, Dept Pharmacol, Madrid 28034, Spain - Author
Camilo Jose Cela Univ Madrid UCJC, Fac Hlth, Castillo Alarcon 49, Madrid 28692, Spain - Author
CSIC, Lab Med Chem, Inst Organ Chem, Juan de la Cierva 3, Madrid 28006, Spain - Author
Hosp 12 Octubre Res Inst, Neuropsychopharmacol Unit, Madrid 28041, Spain - Author
Hosp Univ de la Princesa, Inst Hlth Res, Madrid 28006, Spain - Author
ISCIII, Ctr Biomed Network Res Rare Dis CIBERER, CIBER, Madrid 28040, Spain - Author
Univ Alcala, Dept Quim Organ & Quim Inorgan, Ctra Madrid Barcelona Km 33-6, Alcala De Henares 28871, Spain - Author
Univ Ljubljana, Fac Pharm, Ljubljana 1000, Slovenia - Author
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Abstract

Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is being sought that focuses on the control and scavenging of highly toxic reactive oxygen species by appropriate small molecules, such as nitrones with antioxidant properties. In this context, herein we report here the synthesis, antioxidant, and neuroprotective properties of twelve novel polyfunctionalized alpha-phenyl-tent-butyl(benzyl)nitrones. The antioxidant capacity of these nitrones was investigated by various assays, including the inhibition of lipid peroxidation induced by AAPH, hydroxyl radical scavenging assay, ABTS(+)-decoloration assay, DPPH scavenging assay, and inhibition of soybean lipoxygenase. The inhibitory effect on monoamine oxidases and cholinesterases and inhibition of beta-amyloid aggregation were also investigated. As a result, (Z)-N-benzyl-1-(2-(3-(piperidin-1-yl)propoxy)phenyl)methanimine oxide (5) was found to be one of the most potent antioxidants, with high ABTS(+) scavenging activity (19%), and potent lipoxygenase inhibitory capacity (IC50 = 10 mu M), selectively inhibiting butyrylcholinesterase (IC50 = 3.46 +/- 0.27 mu M), and exhibited neuroprotective profile against the neurotoxicant okadaic acid in a neuronal damage model. Overall, these results pave the way for the further in-depth analysis of the neuroprotection of nitrone 5 in in vitro and in vivo models of stroke and possibly other neurodegenerative diseases in which oxidative stress is identified as a critical player.
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Keywords

Alpha-phenyl-tert-butyl(benzyl)nitronesAntioxidantsButyrylcholinesteraseDiseaseFree radical scavengersGrowthNeuroprotectionPhenylΑ-phenyl-tert-butyl(benzyl)nitrones

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 6/60, thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science & Technology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • WoS: 6
  • Scopus: 6
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 7.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Greece; Slovenia.

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Awards linked to the item

This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2015-65586-R) to JMC and Slovenian Research Agency ARRS (core program funding P1-0208). JMC thanks UCJC (Grants "OPTICOMC903" and "NACONT") for the continued support. DDI thanks the Spanish Ministry of Science, Innovation, and Universities for the predoctoral FPU grant.
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