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Grant support

This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (AGL2017-84614-C2-1-R), the Autonomous Community of Madrid (project ALIBIRD-CMS-2013/ABI-2728) and Spanish Danone Institute. L.C. Julio-Gonzalez thanks the governorship of Bolivar-Colombia for the scholarship granted in the project "Bolivar gana con Ciencia". "L.R-A. thanks the Spanish Research Council (CSIC) and the Spanish Ministry of Economy, Industry and Competitiveness for a Juan de la Cierva contract". We also thank Rosa Sedano of the GC service of SIdI-UAM for help in the SPME-MS analyses.

Analysis of institutional authors

Julio Gonzalez, Lesbia CristinaAuthor

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May 23, 2022
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Purification of lactulose derived-galactooligosaccharides from enzymatic reaction mixtures

Publicated to:INTERNATIONAL DAIRY JOURNAL. 85 79-85 - 2018-10-01 85(), DOI: 10.1016/j.idairyj.2018.04.013

Authors: Cristina Julio-Gonzalez, Lesbia; Ruiz-Aceituno, Laura; Corzo, Nieves; Olano, Agustin;

Affiliations

UAM, CSIC, CEI, Inst Food Sci Res CIAL,Dept Bioact & Food Anal, C Nicolas Cabrera 9, E-28049 Madrid, Spain - Author

Abstract

This study compares two different procedures for purification of lactulose-derived gal-actooligosaccharides (GOS) using fresh Saccharomyces cerevisiae yeast or activated charcoal with water or ethanol/water solutions for selective removal of monosaccharides. Yeast fermentation allowed the complete removal of monosaccharides without any losses of di-and oligosaccharides; however besides ethanol, glycerol and higher alcohols difficult to remove are also produced. The presence of higher alcohols affects the sensory quality of the lactulose-derived GOS and may limit its use in certain food applications. Fractionation of these oligosaccharides using activated charcoal was compared with that of lactose-derived GOS the latter being the most strongly adsorbed. When water was utilised as solvent, all monosaccharides were removed, as well as about 20% of unreacted disaccharides. Removal of tri-, tetra- and pentasaccharides was not observed. Using water/ethanol mixtures, desorption of oligosaccharides increased with ethanol content, allowing the selective recovery of different sugar fractions. (C) 2018 Elsevier Ltd. All rights reserved.

Keywords

Activated-charcoalFermentationHoneyLactoseMicrobiotaOligosaccharidesSeparation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL DAIRY JOURNAL due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.48, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 8
  • Scopus: 12

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 31 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (JULIO GONZALEZ, LESBIA CRISTINA) .