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Analysis of institutional authors

Martínez-Serrano AAuthor

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June 22, 2020
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Article

3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices

Publicated to:Advanced Science. 7 (16): 2001150- - 2020-08-01 7(16), DOI: 10.1002/advs.202001150

Authors: Kajtez J; Buchmann S; Vasudevan S; Birtele M; Rocchetti S; Pless CJ; Heiskanen A; Barker RA; Martínez-Serrano A; Parmar M; Lind JU; Emnéus J

Affiliations

Danmarks Tekniske Universitet - Author
John van Geest Centre for Brain Repair - Author
Lund Univ, Dept Expt Med Sci, Wallenberg Neurosci Ctr, Div Neurobiol, S-22184 Lund, Sweden - Author
Lund Univ, Lund Stem Cell Ctr, BMC A11, S-22184 Lund, Sweden - Author
Stamcellscentrum - Author
Tech Univ Denmark, Dept Biotechnol & Biomed DTU Bioengn, Bldg 423, DK-2800 Lyngby, Denmark - Author
Tech Univ Denmark, Dept Healthcare Technol DTU Hlth Tech, Bldg 423, DK-2800 Lyngby, Denmark - Author
UAM, CSIC, Ctr Mol Biol Severo Ochoa, Dept Mol Neuropathol, Nicolas Cabrera 1, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Dept Mol Biol, Nicolas Cabrera 1, Madrid 28049, Spain - Author
Univ Cambridge, Dept Neurol, Dept Clin Neurosci, Cambridge CB2 1TN, England - Author
Univ Cambridge, John Geest Ctr Brain Repair, Cambridge CB2 1TN, England - Author
Univ Cambridge, WT MRC Cambridge Stem Cell Inst, Cambridge CB2 1TN, England - Author
Universidad Autónoma de Madrid - Author
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Abstract

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Compartmentalized microfluidic platforms are an invaluable tool in neuroscience research. However, harnessing the full potential of this technology remains hindered by the lack of a simple fabrication approach for the creation of intricate device architectures with high-aspect ratio features. Here, a hybrid additive manufacturing approach is presented for the fabrication of open-well compartmentalized neural devices that provides larger freedom of device design, removes the need for manual postprocessing, and allows an increase in the biocompatibility of the system. Suitability of the method for multimaterial integration allows to tailor the device architecture for the long-term maintenance of healthy human stem-cell derived neurons and astrocytes, spanning at least 40 days. Leveraging fast-prototyping capabilities at both micro and macroscale, a proof-of-principle human in vitro model of the nigrostriatal pathway is created. By presenting a route for novel materials and unique architectures in microfluidic systems, the method provides new possibilities in biological research beyond neuroscience applications.

Keywords

3d printingcompartmentalized devicesfast prototypinghuman neural stem cellsneurite guidancenigrostriatal pathwaySoft lithography

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Advanced Science due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 18/335, thus managing to position itself as a Q1 (Primer Cuartil), in the category Materials Science, Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.45. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.92 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 6.66 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 31
  • Scopus: 35
  • Europe PMC: 19

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 111.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 118 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.35.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Denmark; Sweden; United Kingdom.