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Analysis of institutional authors

Carretero VjAuthorálvarez-Merz IAuthorEgea JAuthorHernandez-Guijo JmAuthor

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November 6, 2023
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Review

Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

Publicated to:Antioxidants. 12 (10): 1844- - 2023-10-01 12(10), DOI: 10.3390/antiox12101844

Authors: Carretero, Victoria Jimenez; Ramos, Eva; Segura-Chama, Pedro; Hernandez, Adan; Baraibar, Andres M; Alvarez-Merz, Iris; Munoz, Francisco Lopez; Egea, Javier; Solis, Jose M; Romero, Alejandro; Hernandez-Guijo, Jesus M

Affiliations

Achucarro Basque Center for Neuroscience - Author
Hosp 12 Octubre, Neuropsychopharmacol Unit, Res Inst I 12, Avda Cordoba S-N, Madrid 28041, Spain - Author
Hosp Ramon & Cajal, Neurobiol Res Serv, Carretera Colmenar Viejo,Km 9, Madrid 28029, Spain - Author
Hosp Ramon & Cajal, Ramon y Cajal Inst Hlth Res IRYCIS, Carretera Colmenar Viejo,Km 9, Madrid 28029, Spain - Author
Hosp Univ Princesa, Hosp Univ Santa Cristina, Hlth Res Inst, Mol Neuroinflammat & Neuronal Plast Res Lab, Madrid 28006, Spain - Author
Hospital Universitario Ramón y Cajal - Author
Hospital Universitario Santa Cristina - Author
Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Mexico CONAHCYT, Calzada Mexico Xochimilco 101, Mexico City 14370, Mexico - Author
Instituto de Investigación Hospital 12 de Octubre , Universidad Camilo José Cela - Author
Instituto Nacional de Psiquiatria Ramon de la Fuente - Author
Instituto Teófilo Hernando de I+D del Medicamento - Author
Instituto Teófilo Hernando de I+D del Medicamento , Hospital Universitario Ramón y Cajal - Author
UNAM campus Juriquilla - Author
Univ Autonoma Madrid, Teofilo Hernando Inst, Fac Med, Dept Pharmacol & Therapeut, Ave Arzobispo Morcillo 4, Madrid 28029, Spain - Author
Univ Camilo Jose Cela, Fac Hlth Sci, C Castillo Alarcon 49, Madrid 28692, Spain - Author
Univ Complutense Madrid, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain - Author
Univ Nacl Autonoma Mexico, Inst Neurobiol, Santiago De Queretaro 76230, Queretaro, Mexico - Author
Univ Pais Vasco UPV EHU, Achucarro Basque Ctr Neurosci, Dept Neurociencias, Barrio Sarriena S-N, Leioa 48940, Spain - Author
Universidad Complutense de Madrid - Author
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Abstract

The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered significant attention in recent years due to its diverse physiological functions and potential therapeutic benefits by reducing oxidative stress, inflammation, and apoptosis. Melatonin has been found to mitigate ischemic brain damage caused by stroke. By scavenging free radicals and reducing oxidative damage, melatonin may help slow down the aging process and protect against age-related cognitive decline. Additionally, non-excitatory amino acids have been shown to possess neuroprotective properties, including antioxidant and anti-inflammatory in stroke and aging-related conditions. They can attenuate oxidative stress, modulate calcium homeostasis, and inhibit apoptosis, thereby safeguarding neurons against damage induced by stroke and aging processes. The intracellular accumulation of certain non-excitatory amino acids could promote harmful effects during hypoxia-ischemia episodes and thus, the blockade of the amino acid transporters involved in the process could be an alternative therapeutic strategy to reduce ischemic damage. On the other hand, the accumulation of free radicals, specifically mitochondrial reactive oxygen and nitrogen species, accelerates cellular senescence and contributes to age-related decline. Recent research suggests a complex interplay between melatonin, free radicals, and non-excitatory amino acids in stroke and aging. The neuroprotective actions of melatonin and non-excitatory amino acids converge on multiple pathways, including the regulation of calcium homeostasis, modulation of apoptosis, and reduction of inflammation. These mechanisms collectively contribute to the preservation of neuronal integrity and functions, making them promising targets for therapeutic interventions in stroke and age-related disorders.

Keywords

agingblood-brain-barriercarbon-monoxidecerebrospinal-fluidfree radicalsmelatoninnitric-oxide synthasenon-excitatory amino acidsoxidative stressprotein-kinase-iireactive oxygensleep-wake syndromesmooth-muscle contractionstrokeAgingFocal cerebral-ischemiaFree radicalsMelatoninNon-excitatory amino acidsStroke

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 8/72, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.88, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-08, the following number of citations:

  • WoS: 4
  • Scopus: 1
  • Europe PMC: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 20.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 26 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/719556

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Canada; Mexico.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (JIMENEZ CARRETERO, VICTORIA) and Last Author (HERNANDEZ GUIJO, JESUS MIGUEL).