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Analysis of institutional authors

Herrero JmAuthorFabra DAuthorMatesanz AiAuthorSánchez-Perez ICorresponding AuthorQuiroga AgCorresponding Author

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June 12, 2023
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Dithiobiureas Palladium(II) complexes' studies: From their synthesis to their biological action

Publicated to:JOURNAL OF INORGANIC BIOCHEMISTRY. 246 112261- - 2023-09-01 246(), DOI: 10.1016/j.jinorgbio.2023.112261

Authors: Herrero, Jorge M; Herrero, Jorge M; Fabra, David; Matesanz, Ana I; Matesanz, Ana I; Hernandez, Carolina; Sanchez-Perez, Isabel; Quiroga, Adoracion G; Quiroga, Adoracion G

Affiliations

Inst Ramon y Cajal Invest Sanitaria IRYCIS, Canc Stem Cell & Fibroinflammatory Microenvironm G, Chron Dis & Canc Area 3, Madrid, Spain - Author
Instituto Ramón y Cajal de Investigación Sanitaria , Facultad de Medicina de la Universidad Autónoma de Madrid - Author
Univ Autonoma Madrid, Fac Ciencias & IadChem, Dept Quim Inorgan, Calle Francisco Tomas & Valiente 7, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Fac Med, Dept Bioquim, Madrid 28029, Spain - Author
Univ Autonoma Madrid, Inst Invest Biomed Albert Sols, Madrid 28029, Spain - Author
Univ Castilla La Mancha, Fac Ciencias Medio Ambiente, Dept Quim Inorgan Organ & Bioquim, Avd Carlos III S-N, Toledo 45071, Spain - Author
Universidad Autónoma de Madrid - Author
Universidad de Castilla-La Mancha - Author
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Abstract

Dithiobiureas coordination chemistry towards palladium (II) ions and their possible application is presented and discussed. 1,6-(4-Methoxyphenyl)-2,5-dithiobiurea and 1,6-(4-chlorophenyl)-2,5-dithiobiurea afford two Pd(II) complexes with the general formula [Pd2(H2L)Cl2(PPh3)2]. The metal ion forms one chelate ring with the dithiobiurea, and binds to a triphenylphosphine and an additional leaving group cisplatin like. One of the complexes (1) is endowed not only with stability in DMSO and aqua solutions containing a biological buffer but also with cytotoxicity versus gastric cancer cell lines. Complex 1 does not interact covalently to DNA models, neither activates p53 or Checkpoint Kinase 1 key proteins for DNA damage response. Thus, we propose that complex 1 exerts its action by activating Mitogen-Activated Protein Kinases [p38, Extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs)] as cell death inductors.

Keywords

activationapoptosisbindingcrystal-structurescytotoxic activitydithiobiureadnadna damagegastric cancermap kinasept(ii) complexesresistanttumor-cells2,5-dithiobiurea h(2)dtbuDithiobiureaDna damageGastric cancerJnk mitogen-activated protein kinasesMap kinaseMetallodrugMitogen-activated protein kinasesPalladiumPhosphorylationSignal transduction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF INORGANIC BIOCHEMISTRY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 10/44, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Inorganic & Nuclear.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.55, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-30, the following number of citations:

  • WoS: 7
  • Scopus: 7
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-30:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 4.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 9 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.35.
  • The number of mentions on the social network X (formerly Twitter): 10 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MELONES HERRERO, JORGE) and Last Author (GOMEZ QUIROGA, ADORACION).

the authors responsible for correspondence tasks have been SANCHEZ PEREZ, MARIA ISABEL and GOMEZ QUIROGA, ADORACION.