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Vera IAuthorGisbert J.p.AuthorMartín-Arranz M.d.Author

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Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

Publicated to:Frontiers of Medicine. 9 823900- - 2022-02-01 9(), DOI: 10.3389/fmed.2022.823900

Authors: Gutiérrez A; Zapater P; Ricart E; González-Vivó M; Gordillo J; Olivares D; Vera I; Mañosa M; Gisbert JP; Aguas M; Sánchez-Rodríguez E; Bosca-Watts M; Laredo V; Camps B; Marín-Jiménez I; Zabana Y; Martín-Arranz MD; Muñoz R; Navarro M; Sierra E; Madero L; Vela M; Pérez-Calle JL; Sainz E; Calvet X; Arias L; Morales V; Bermejo F; Fernández-Salazar L; Van Domselaar M; De Castro L; Rodríguez C; Muñoz-Villafranca C; Lorente R; Rivero M; Iglesias E; Herreros B; Busquets D; Riera J; Martínez-Montiel MP; Roldón M; Roncero O; Hinojosa E; Sierra M; Barrio J; De Francisco R; Huguet J; Merino O; Carpio D; Ginard D; Muñoz F; Piqueras M; Almela P; Argüelles-Arias F; Alcaín G; Bujanda L; Manceñido N; Lucendo AJ; Varela P; Rodríguez-Lago I; Ramos L; Sempere L; Sesé E; Barreiro-de Acosta M; Domènech E; Francés R

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Abstract

Background: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Methods: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. Results: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Conclusions: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

Keywords

biologicscrohn's diseaseimmigrantinflammatory bowel diseasephenotypeBiologicsCrohn's diseaseImmigrantInflammatory bowel diseasePhenotypeUlcerative colitis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers of Medicine due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 20/136, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, Research & Experimental.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.36, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 3.14 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-05, the following number of citations:

  • WoS: 3
  • Scopus: 6
  • OpenCitations: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 61.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 60 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 10.6.
  • The number of mentions on the social network X (formerly Twitter): 19 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/712051

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.