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This work was supported by a grant from the Consejeria de Salud de la Junta de Andalucia (project PI-0001/2017), and partially founded by the Instituto de Salud Carlos III (Projects PI16/01443 and PI19/01312), integrated in the national I+D+i 2013-2016, 2016-2019, and co-funded by the European Union (ERDF/ESF, "Investing in your future"), by the Spanish Network for AIDS investigation (RIS) (www.red.es/redes/inicio (accessed on 1 January 2021)) (RD16/0025/0040), as a part of the Nacional I+ D+I, ISCIII Subdireccion General de Evaluacion and the European Fund for Development of Regions (FEDER) and by GEHEP-SEIMC (GEHEP-011 project). J.A.P. has received a research extension grant from the Programa de Intensificacion de la Actividad de Investigacion del Servicio Nacional de Salud Carlos III (I3SNS). A.C.-G. has received a Rio Hortega grant from the Instituto de Salud Carlos III (grant number CM19/00251). A.G.-S. is the recipient of a Miguel Servet Research Contract by Instituto de Salud Carlos III (CP18/00146). I.R. is the recipient of a P-FIS Research Contract by Instituto de Salud Carlos IIII (FI20/00215). A.Ruiz. is supported by national grants PI13/02434, PI16/01861 and PI19/01301. Accion Estrategica en Salud is integrated into the Spanish National R+ D+ I Plan and funded by ISCIII (Instituto de Salud Carlos III), Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER "Una manera de Hacer Europa") and received support from the European Union/EFPIA Innovative Medicines Initiative Joint Undertaking ADAPTED and MOPEAD projects (Grants No. 115975 and 115985) and PREADAPT project (JPco-fuND-2. Grant number AC19/00097).

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De Los Santos, IAuthor

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Article

A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure

Publicated to:Diagnostics. 11 (8): 1501- - 2021-08-01 11(8), DOI: 10.3390/diagnostics11081501

Authors: Corma-Gomez, Anais; Macias, Juan; Rivero, Antonio; Rivero-Juarez, Antonio; de los Santos, Ignacio; Reus-Banuls, Sergio; Morano, Luis; Merino, Dolores; Palacios, Rosario; Galera, Carlos; Fernandez-Fuertes, Marta; Gonzalez-Serna, Alejandro; de Rojas, Itziar; Ruiz, Agustin; Saez, Maria E.; Real, Luis M.; Pineda, Juan A.;

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Abstract

Liver stiffness (LS) at sustained virological response (SVR) after direct-acting antivirals (DAA)-based therapy is a predictor of liver events in hepatitis C virus (HCV)-infected patients. The study aim was to identify genetic factors associated with LS changes from the moment of starting anti-HCV therapy to SVR. This prospective study included HCV-infected patients from the GEHEP-011 cohort who achieved SVR with DAA-based therapy, with LS pre-treatment >= 9.5 kPa and LS measurement available at SVR. Plink and Magma software were used to carry out genome-wide single-nucleotide polymorphism (SNP)-based and gene-based association analyses, respectively. The ShinyGO application was used for exploring enrichment in Gene Ontology (GO) categories for biological processes. Overall, 242 patients were included. Median (quartile 1, quartile 3) LS values at pre-treatment and at SVR were 16.8 (12, 28) kPa and 12.0 (8.5, 19.3) kPa, respectively. Thirty-five SNPs and three genes reached suggestive association with LS changes from the moment of starting anti-HCV therapy to SVR. GO categories related to DNA packaging complex, DNA conformation change, chromosome organization and chromatin organization were significantly enriched. Our study reports possible genetic factors associated with LS changes during HCV-infection cure. In addition, our results suggest that processes related to DNA conformation are also involved in these changes.

Keywords

direct-acting antiviralsgwashepatitis c virus infectionliver stiffnesspolymorphismsContributesDirect-acting antiviralsFibrosisGwasHepatitis c virus infectionLiver stiffnessPolymorphismsProgressionRiskSustained virological response

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Diagnostics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 60/172, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine, General & Internal. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Clinical Biochemistry.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-06:

  • WoS: 2
  • Scopus: 2
  • OpenCitations: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 12.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.1.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 13 (Altmetric).