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Analysis of institutional authors

Rodriguez, AdAuthorDe Nova, JlmCorresponding AuthorPardo, RsAuthorMartin-Perez, EAuthor

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July 16, 2021
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Oxyphil cells in primary hyperparathyroidism: a clinicopathological study

Publicated to:Hormones-International Journal of Endocrinology and Metabolism. 20 (4): 715-721 - 2021-07-06 20(4), DOI: 10.1007/s42000-021-00305-2

Authors: De la Hoz Rodriguez, Angela; Munoz De Nova, Jose Luis; Munoz Hernandez, Patricia; Valdes de Anca, Alvaro; Serrano Pardo, Rosario; Tovar Perez, Rodrigo; Martin-Perez, Elena;

Affiliations

Hosp Univ La Princesa, Gen Surg Dept, C Diego de Leon 62,4th Floor, Madrid 28006, Spain - Author
Hosp Univ La Princesa, Pathol Dept, Madrid, Spain - Author
Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain - Author
Univ Autonoma Madrid UAM, Madrid, Spain - Author

Abstract

Background The role of oxyphil cells (OxC) in primary hyperparathyroidism (PHPT) still remains controversial. Historically, they were believed to be involuted cells. However, they could play an important role in hormone secretion. The clinical behavior of OxC-rich adenomas and preoperative PHPT localization tests have been widely studied. The aim of this study is to analyze the implications of OxC in PHTP. Methods A retrospective cohort study of patients undergoing parathyroidectomy for PHPT was conducted. Additionally, we included normal glands removed in the context of PHPT or inadvertently during a thyroidectomy. All glands were reviewed independently by three researchers, performing a semi-quantitative analysis of the percentage of OxC. Groups with < 25% OxC and > 75% OxC were compared. Results In the period 2010-2017, 238 patients and 261 removed glands were included (8.8% OxCA > 75%). There were no differences in symptomatology and levels of preoperative calcium, parathormone, or 25-OH vitamin. Patients with OxCA > 75% had worse preoperative glomerular filtration rate (81.2 vs. 69.7 mL/min/1.73 m(2); p = 0.043). They also had a trend towards larger size and weight (17 vs. 20 mm, p = 0.135 and 562 vs. 875 mg, p = 0.495), while ultrasound was found to have better accuracy (48.3% vs. 73.7%; p = 0.035). There were no normal glands with a content of OxC > 75%. Conclusions Our study suggests that phosphocalcic metabolism is not influenced by the presence of a high content of OxC in the parathyroid glands. A high content of OxC seems to be exclusive to pathologic glands and could be related to the deterioration of renal function in patients with PHPT.

Keywords

oxyphil cellsparathyroid gland99m sestamibi scansAdenomasOxyphil cellsParathyroid glandParathyroid-glandsPreoperative localizationPrimary hyperparathyroidismScintigraphyWeight

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Hormones-International Journal of Endocrinology and Metabolism due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.79, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-29, the following number of citations:

  • WoS: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-29:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rodriguez Escudero, Alvaro Daniel) and Last Author (MARTIN PEREZ, MARIA ELENA).

the author responsible for correspondence tasks has been MUÑOZ DE NOVA, JOSE LUIS.