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Pérez-Illana M.AuthorMartín-González N.Author

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May 24, 2021
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Adenovirus structure: What is new?

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22 (10): 5240- - 2021-05-02 22(10), DOI: 10.3390/ijms22105240

Authors: Gallardo, Jose; Perez-Illana, Marta; Martin-Gonzalez, Natalia; San Martin, Carmen

Affiliations

CSIC - Centro Nacional de Biotecnologia (CNB) - Author
Ctr Nacl Biotecnol CNB CSIC, Dept Macromol Struct, Madrid 28049, Spain - Author
Univ Autonoma Madrid UAM, Dept Condensed Matter Phys, Madrid 28049, Spain - Author
Universidad Autónoma de Madrid - Author

Abstract

Adenoviruses are large (~950 Å) and complex non-enveloped, dsDNA icosahedral viruses. They have a pseudo-T = 25 triangulation number with at least 12 different proteins composing the virion. These include the major and minor capsid proteins, core proteins, maturation protease, terminal protein, and packaging machinery. Although adenoviruses have been studied for more than 60 years, deciphering their architecture has presented a challenge for structural biology techniques. An outstanding event was the first near-atomic resolution structure of human adenovirus type 5 (HAdV-C5), solved by cryo-electron microscopy (cryo-EM) in 2010. Discovery of new adenovirus types, together with methodological advances in structural biology techniques, in particular cryoEM, has lately produced a considerable amount of new, high-resolution data on the organization of adenoviruses belonging to different species. In spite of these advances, the organization of the nonicosahedral core is still a great unknown. Nevertheless, alternative techniques such as atomic force condensation and virion stability. Here we summarize the current knowledge on adenovirus structure, with an emphasis on high-resolution structures obtained since 2010.

Keywords

adenoviruscore proteinscryo-electron microscopycryo-emcrystallographymaturationminor coat proteinsAdenoviridaeAdenovirusCapsid proteinsCore proteinsCryo-electron microscopyCryo-emCrystallographyMaturationMicroscopy, atomic forceMinor coat proteinsPenton protein, adenovirusStructureViral proteinsVirionVirus internalization

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/297, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 4.98. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.71 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 14.87 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-21, the following number of citations:

  • WoS: 56
  • Scopus: 57
  • Europe PMC: 38

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 192.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 155 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 18.85.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).
  • The number of mentions on Wikipedia: 2 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.