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Grant support

We acknowledge the financial support by the Spanish Government (RTI2018-095038-B-I00) and ERC (ERC-CG, 647550). S.C. thanks the Ministerio de Ciencia e Innovacion for a Juan de la Cierva contract. M. J. C. thanks the Comunidad Autonoma de Madrid for a postdoctoral contract (PEJD-2018POST/AMB-8938). L. M. thanks the Comunidad Autonoma de Madrid for a postdoctoral contract (PEJD-2018-POST/AMB-8938), and for an Atraccion de Talento Investigador contract (2017-T2/AMB-5037). The authors also wish to thank the Comunidad de Madrid and European Structural Funds for their financial support to FotoArt-CM project (S2018/NMT-4367).

Analysis of institutional authors

Cabrera-Afonso, Maria JesusAuthorCembellin, SaraCorresponding AuthorBerton, MAuthorMarzo, LeyreAuthorMaestro, M CarmenCorresponding AuthorAleman, JoseCorresponding Author

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November 23, 2020
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Article

Metal-free visible light-promoted synthesis of isothiazoles: a catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions

Publicated to:GREEN CHEMISTRY. 22 (20): 6792-6797 - 2020-10-21 22(20), DOI: 10.1039/d0gc02618b

Authors: Cabrera-Afonso, Maria Jesus; Cembellin, Sara; Halima-Salem, Adnane; Berton, Mateo; Marzo, Leyre; Miloudi, Abdellah; Maestro, M. Carmen; Aleman, Jose;

Affiliations

Ecole Natl Polytech Oran & Maurice Audin, Dept Classes Preparatoires Sci & Technol, BP1523, El Mnaouer 31100, Oran, Algeria - Author
Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Organ Chem Dept, Modulo 1, Madrid 28049, Spain - Author
Univ Oran 1, Fac Sci Exactes & Appl, Dept Chim, Lab Chim Fine, Oran-1,BP1524, El Mnaouer 31100, Oran, Algeria - Author

Abstract

A sustainable synthesis of isothiazoles has been developed using an alpha-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromentally friendly option to prepare these highly valuable heterocycles. Furthermore, the synthetic value of the method is highlighted by the preparation of a natural product derivative and the implementation of the reaction in a continuous flow setup.

Keywords

AlkylationBenzisothiazolesComplexesCyclizationDerivativesFunctionalizationsNitrogen-centered radicalsOximesPhotocatalysisPhytoalexins brassilexin

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal GREEN CHEMISTRY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 2/44, thus managing to position itself as a Q1 (Primer Cuartil), in the category Green & Sustainable Science & Technology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.9, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-03, the following number of citations:

  • WoS: 15
  • Scopus: 17

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 32.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 32 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 22.45.
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/699584

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Algeria.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CABRERA AFONSO, MARIA JESUS) and Last Author (ALEMAN LARA, JOSE JULIAN).

the authors responsible for correspondence tasks have been CEMBELLIN SANTOS, SARA, MAESTRO RUBIO, CARMEN and ALEMAN LARA, JOSE JULIAN.