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Analysis of institutional authors

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May 31, 2020
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P Ka Modulation of Pyrrolidine-Based Catalytic Polymers Used for the Preparation of Glycosyl Hydrazides at Physiological pH and Temperature

Publicated to: ACS Applied Bio Materials. 3 (4): 1955-1967 - 2020-04-20 3(4), DOI: 10.1021/acsabm.9b01123

Authors:

Vargas, Emily L; Vargas, Emily L; Antonio Velazquez, J; Antonio Velazquez, J; Rodrigo, Eduardo; Reinecke, Helmut; Rodriguez-Hernandez, Juan; Fernandez-Mayoralas, Alfonso; Gallardo, Alberto; Belen Cid, Maria
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Affiliations

CSIC - Instituto de Ciencia y Tecnologia de Polimeros (ICTP) - Author
CSIC - Instituto de Química Orgánica General IQOG - Author
Inst Ciencia & Tecnol Polimeros ICTP CSIC, Madrid 28006, Spain - Author
Inst Quim Organ Gen IQOG CSIC, Madrid 28006, Spain - Author
Univ Autonoma Madrid Cantoblanco, Dept Organ Chem, Madrid 28049, Spain - Author
Universidad Autónoma de Madrid - Author
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Abstract

Copyright © 2020 American Chemical Society. Inspired by the ability of enzymes to use the surrounding hydrophobic and/or polarizable groups to modulate the pKa of a given amino acid, we designed a series of soluble polymers able to decrease the basicity of pyrrolidine (from 11.2 to 8.6 pKa units), which clearly increases its aminocatalytic activity at physiological pH in C═N bond formation reactions via ion iminium activation. Other parameters such as charge density, hydrophobic/hydrophilic balance, and aggregation state have been studied as important factors in the catalytic activity of the polymers for a given substrate. To demonstrate the utility of our approach, an optimal pyrrolidine-based catalytic polymer has been used for the formation of C-N bonds between hydrazides and free sugars as the model system for the preparation of glycoconjugates.
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Keywords

enzyme-like organocatalysishydrazonesiminium activationpka modulationpolymersAlpha-nucleophilesAsymmetric aldol reactionChemistryCopolymersEnzyme-lace organocatalysisEnzyme-like organocatalysisHydrazone formationHydrazonesIminium activationMechanismNanoparticlesNucleophilic catalysisOrganocatalystOxime ligationP k modulation aPolymersPyrrolidinePyrrolidine pk(a) modulation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ACS Applied Bio Materials due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Biomedical Engineering.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • WoS: 2
  • Scopus: 2
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Vargas EL) and Last Author (CID DE LA PLATA, MARIA BELEN).

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