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Analysis of institutional authors

Soto-Heredero GAuthorMittelbrunn MCorresponding Author

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Interorganelle communication between mitochondria and the endolysosomal system

Publicated to:Frontiers in Cell and Developmental Biology. 5 (NOV): 95- - 2017-11-07 5(NOV), DOI: 10.3389/fcell.2017.00095

Authors: Soto-Heredero, Gonzalo; Baixauli, Francesc; Mittelbrunn, Maria

Affiliations

CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM) - Author
Hosp 12 Octubre, Inst Invest, Madrid, Spain - Author
Hospital Universitario 12 de octubre - Author
Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany - Author
Max Planck Institute of Immunobiology and Epigenetics - Author
UAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain - Author
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Abstract

© 2017 Soto-Heredero, Baixauli and Mittelbrunn. The function of mitochondria and lysosomes has classically been studied separately. However, evidence has now emerged of intense crosstalk between these two organelles, such that the activity or stress status of one organelle may affect the other. Direct physical contacts between mitochondria and the endolysosomal compartment have been reported as a rapid means of interorganelle communication, mediating lipid or other metabolite exchange. Moreover, mitochondrial derived vesicles can traffic obsolete mitochondrial proteins into the endolysosomal system for their degradation or secretion to the extracellular milieu as exosomes, representing an additional mitochondrial quality control mechanism that connects mitochondria and lysosomes independently of autophagosome formation. Here, we present what is currently known about the functional and physical communication between mitochondria and lysosomes or lysosome-related organelles, and their role in sustaining cellular homeostasis.

Keywords

agingautophagyexosomeslysosomeproteostasisAgingAutophagyEndoplasmic-reticulumErExosomesLife-spanLysosomeMaintenanceMechanismsMelanosomesMembranesProteostasisQuality controlQuality-controlVacuoles

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers in Cell and Developmental Biology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Cell Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 2.28, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 7.67 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-20, the following number of citations:

  • WoS: 74
  • Scopus: 81
  • Europe PMC: 59
  • OpenCitations: 81

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 169.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 169 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.25.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SOTO HEREDERO, GONZALO) and Last Author (MITTELBRUNN HERRERO, MARIA).

the author responsible for correspondence tasks has been MITTELBRUNN HERRERO, MARIA.