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Analysis of institutional authors

Palma-Cobo, MiguelAuthorYanez-Mo, MariaAuthorCabanas, CarlosCorresponding Author

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December 13, 2024
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Review

Molecular determinants involved in the docking and uptake of tumor-derived extracellular vesicles: implications in cancer

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25 (6): 3449- - 2024-03-01 25(6), DOI: 10.3390/ijms25063449

Authors: Clares-Pedrero, Irene; Rocha-Mulero, Almudena; Palma-Cobo, Miguel; Cardenes, Beatriz; Yanez-Mo, Maria; Cabanas, Carlos

Affiliations

Ctr Biol Mol Severo Ochoa CSIC UAM, Tissue & Organ Homeostasis Program, Cell Cell Commun Unit, Madrid 28049, Spain - Author
Inst Invest Sanitaria Hosp Princesa IIS IP, Madrid 28006, Spain - Author
Univ Autonoma Madrid, Dept Biol Mol, IUBM, Madrid 28049, Spain - Author

Abstract

Extracellular vesicles produced by tumor cells (TEVs) influence all stages of cancer development and spread, including tumorigenesis, cancer progression, and metastasis. TEVs can trigger profound phenotypic and functional changes in target cells through three main general mechanisms: (i) docking of TEVs on target cells and triggering of intra-cellular signaling; (ii) fusion of TEVs and target cell membranes with release of TEVs molecular cargo in the cytoplasm of recipient cell; and (iii) uptake of TEVs by recipient cells. Though the overall tumor-promoting effects of TEVs as well as the general mechanisms involved in TEVs interactions with, and uptake by, recipient cells are relatively well established, current knowledge about the molecular determinants that mediate the docking and uptake of tumor-derived EVs by specific target cells is still rather deficient. These molecular determinants dictate the cell and organ tropism of TEVs and ultimately control the specificity of TEVs-promoted metastases. Here, we will review current knowledge on selected specific molecules that mediate the tropism of TEVs towards specific target cells and organs, including the integrins, ICAM-1 Inter-Cellular Adhesion Molecule), ALCAM (Activated Leukocyte Cell Adhesion Molecule), CD44, the metalloproteinases ADAM17 (A Disintegrin And Metalloproteinase member 17) and ADAM10 (A Disintegrin And Metalloproteinase member 10), and the tetraspanin CD9.

Keywords

Adam10Adam17Adhesion receptorsAlcam/cd16Alcam/cd166CarcinogenesisCdCd44Cd9Cell communicationCell-adhesion moleculeDendritic cellsDisintegrinsExosomesExtracellular vesiclesFibronectinHumansIcam-1/cd54IntegrinsOvarian-cancerSerumSoluble cd44TetraspaninsTev dockingTev uptakeTumor-derived extracellular vesicles (tevs)

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 68/231, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Multidisciplinary.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-02:

  • WoS: 1
  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 12 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
    • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/717007

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Clares-Pedrero, Irene) and Last Author (CABAÑAS GUTIERREZ, CARLOS).

    the author responsible for correspondence tasks has been CABAÑAS GUTIERREZ, CARLOS.