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IG thanks the support of the Spanish Ministry of Science and Innovation (MCIN) (PI19/00954, PI23/00822) integrated into the Plan Nacional de I + D + I and cofinanced by the ISCIII-Subdireccion General de Evaluacion y confinanciado por la Union Europea (FEDER, FSE, Next Generation EU/Plan de Recuperacion Transformacion y Resiliencia_PRTR) ; the Instituto de Salud Carlos III; the CIBER of Mental Health (CIBERSAM) ; and the Secretaria d'Universitats i Recerca Departament d'Economia i Coneixement (2021 SGR 01358), CERCA Programme/Generalitat de Catalunya as well as the Fundacio Clinic la Recerca Biomedica (Pons Bartran 2022-FRCB_PB1_2022) .

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Anxious and depressive symptoms and health-related quality of life in a cohort of people who recently attempted suicide: A network analysis

Publicated to:JOURNAL OF AFFECTIVE DISORDERS. 355 210-219 - 2024-04-01 355(), DOI: 10.1016/j.jad.2024.03.109

Authors: Oliva, Vincenzo; Roberto, Natalia; Andreo-Jover, Jorge; Bobes, Teresa; Rivero, Manuel Canal; Cebria, Anabel; Crespo-Facorro, Benedicto; de la Torre-Luque, Alejandro; Diaz-Marsa, Marina; Elices, Matilde; Fernandez-Rodrigues, Veronica; Gonzalez-Pinto, Ana; Tarrero, Angela Palao; Perez-Diez, Ivan; Rodriguez-Vega, Beatriz; Ruiz-Veguilla, Miguel; Saiz, Pilar A; Seijo-Zazo, Elisa; Toll-Privat, Alba; McIntyre, Roger S; Vieta, Eduard; Grande, Iria; Perez-Sola, Victor; De Prisco, Michele; Vazquez, Mireia; Palao, Diego; Ruiz, Igor Merodio; Guinovart, Marti; Comendador, Laura; Justicia, Azucena; Salgado, Purificacion; Alvarez, Pilar; Puigdemont, Dolors; Gil, Isabel Gonzalez; Ayad-Ahmed, Wala; Carrasco, Jose Luis; Mellor-Marsa, Blanca; Lara, Elvira; Sanchez-Fernandez-Quejo, Alberto; Ayuso-Mateos, Jose Luis; Diaz-Carracedo, Patricia; Garcia-Ligero, Elena; Martinez, Manuel Jesus; Giner, Lucas; Lopez, Alvaro; Batanero, Marta Sanchez; Abejas, Daniel; Zorrilla, Inaki; Mar-Barrutia, Lorea

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Abstract

Background: Suicide is an international health concern with immeasurable impact from the perspective of human and social suffering. Prior suicide attempts, anxious and depressive symptoms, and relatively lower healthrelated quality of life (HRQoL) are among the most replicated risk factors for suicide. Our goal was to visualize the distribution of these features and their interconnections with use of a network analysis approach in individuals who recently attempted suicide. Methods: Individuals with a recent suicide attempt were recruited from nine University Hospitals across Spain as part of the SURVIVE cohort study. Anxious and depressive symptoms, and perceived HRQoL were included in the network analysis. Network structures were estimated with the EBICglasso model. Centrality measures and bridge symptoms connecting communities were explored. Subnetworks comparing younger and older individuals, and women and men were analyzed. symptom with the greatest influence in the overall network, followed by anxiety symptoms such as feeling nervous, worrying, restless, and having difficulties to relax. Perceived general health was associated with increased suicidal ideation in the whole sample. Older people showed a specific connection between perceived

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