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Garcia-Rodriguez, JulioAuthor
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Epidemiology and prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium in a tertiary hospital from Madrid, Spain

Publicated to:Revista Espanola de Quimioterapia. 36 (3): 310-313 - 2023-06-01 36(3), DOI: 10.37201/req/123.2022

Authors: Maldonado-Barrueco, Alfredo; Rodriguez-Ayala, Monserrat; Grandioso-Vas, David; Garcia-Clemente, Paloma; Guedez-Lopez, Gladys Virginia; Garcia-Rodriguez, Julio; Quiles-Melero, Inmaculada

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Hosp Univ La Paz, Clin Microbiol & Parasitol Dept, Madrid, Spain - Author

Abstract

Objectives. Mycoplasma genitalium causes persistent sexually transmitted infections. The aims of this study were to estimate the prevalence of resistances to macrolides and fluoroquinolones in M. genitalium and the sexually transmitted coinfections in patients at Hospital Universitario La Paz (Madrid, Spain). Material and methods. Patients attended between January and October 2021 were studied. Screening for sexually transmitted pathogens and detection of 23S rRNA and parC genes mutations were performed by real-time PCR (Allplex, SeegeneTM). Results. A total of 1,518 females and 1,136 males were studied. The prevalence of M. genitalium was 2.1%. The macrolides resistance rate was 51.8%. The mutations found were A2059G, A2058T and A2058G. The rate of resistance to fluoroquinolones was 17.8% being the G248T mutation (S83I) the most frequent. Seven males had some sexual transmitted coinfection. Conclusions. Although the percentage of M. genitalium infections is low, the high rate of resistance to macrolides makes it necessary to revise the protocols for diagnosis and empirical treatment of sexually transmitted infections. The use of fluoroquinolones is appropriate after screening of macrolide resistance profile.

Keywords
Anti-bacterial agentsAzithromycinCoinfectionDrug resistance, bacterialFemaleFluoroquinolonesHumansMacrolidesMaleMoxifloxacinMutationMycoplasma genitaliumMycoplasma infectionsPrevalenceResistanceSpainStStiTertiary care centers

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Revista Espanola de Quimioterapia, and although the journal is classified in the quartile Q3 (Agencia WoS (JCR)), its regional focus and specialization in Pharmacology & Pharmacy, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.96, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-16, the following number of citations:

  • WoS: 1
  • Scopus: 2
  • Europe PMC: 1
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-16:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
    • Additionally, the work has been submitted to a journal classified as Diamond in relation to this type of editorial policy.